Michael, cold fronts and wind reduce insects but be ready with screens and coils. Below Boca Grande visit Cayo Coasta SP for low tide shelling. You can dinghy in,or day dock,or overnight their dock for $20. Punta Bianca Island SE cove, mangrove tunnel dinghy ride backside Cayo Coasta, Cabbage Key for lunch are all close by. Pine Island Sound, J Ding Darling refuge, is full of bird life and have dozens of Nimble size hideaways. Settled weather you could lay behind point Yebel and walk Sanibel Beach near lighthouse. Passage behind Ft Myers Beach may be possible, check your overhead. There's waterways mostly unused between there and Naples that skiffs frequent. Doctors Pass inlet can have strong outflow, is very useable, opening ICW from Naples to Goodland. Plenty of gunkholes including routes to local beach spots appear on map. The Ten Thousands are outstanding. Stop at W end of Whitehorse Key the inside side of sandbar. Rivers between there and Little Shark are suitable. Lostmans River S entry shows old campsite on island and is pretty. Upriver is Watson Place from Mathiesens "Killing Mr.Watson " . Below Cape Sable see Carl Ross Key which is NPS pretty day use spot. Village of Flamingo daunted by hurricanes is NPS headquarters but little else nowadays. Good interpretive materials for Everglades and maybe fuel but check first. East of Flamingo are crocodile and skiff passage to upper Keys. Conventional route is SE to Keys. Lignumvite Key, Indian Key, for history and Marquesas Key past Key West for solitude and adventure. Winds clock from SE around compass with fronts. The late Claiborne Young wrote much on this area. His cruisersnet online is useful. Good luck and report if in Marquasis please - tar