Check the weather window and go. What is it,,, about 300 miles on the line? If you needed to you could motor in 2.5 days as there's no place to stop. You also have some nice places along the way to drop the hook and jump in the water.

Panama City (I thought you really meant on the Caribbean side 'near Panama City") Panama to St. Pete is a real push and probably prone to disaster. The other Panama City seems like a cake walk.

Ha! I guess one has to be specific.