That's lots of time. Apalachachicola is a nice little town on the Pan Handle to stop. There is not much on the "Big Bend" So I would go directly to Steinhatchee (not much there either) or Crystal River or Dunedin. Coming from the North you can take the ICW from Clearwater south to Tampa Bay. If you elect to stay outside, Inlets....I would only use Clearwater, Johns Pass, North channel by Pass a grille and Tierra Verde or the main shipping channel into Tampa bay. I don't know what you draw, but the water is pretty Skinny in this neck of the woods. Check your charts.