Well, I agree with Larry's points 2 and 3 but strongly disagree with his point 1 about the fuse being close to the panel. This is not safe.

The wire from the panel should be sized to take the maximum current from the panel with no harm. In other words that wire from the panel could be connected directly to ground and it wouldn't hurt a thing. The current rating of the wire is called its ampacity and has nothing to do with voltage drop which usually requires even larger wire than the minimum ampacity value. So there is no need for a fuse at the panel if the wire is sized right.

Fuse the wire on the battery end or connect it through an appropriate sized breaker on the main DC panel. You need the fuse/breaker on the battery end of the circuit to protect the wire in case it shorts to ground. Batteries can supply hundreds of amps of current.

David