I find that the split sail plan leaves lots of options, particularly for single handed sailing. When I go out I set the mizzen first. I then use the mizzen to turn the boat off the wind, drop the mooring and unroll the genoa and I am sailing. The boat points a little bit higher with the main up, but not enough to bother with the main most of the time. I do set the main if the wind is light (say under 10-12 knots). Many people argue that the extra drag from the mizzen slows the boat. Well, I find that the added convenience of sailing jib and jigger more than offsets that. In any wind over 15 knots the boat will make hull speed without the main. Down wind I like sailing without the main because it is easy to set the mizzen and jib wing on wing. On my boat, most of the drive is from the 150% genoa which has 40% more area than the main. The only down side to going down wind without the main is that a significant wind gust can turn the boat onto a reach if you aren't actively steering.
On the down side, you do have the extra rigging to deal with. I can't put my radar on a stern mounted pole, but the mizzen makes a nice platform for it. The locations of my mizzen aft lower shrouds als limit me to a 10" winch handle, which makes sheeting in the jib a bit harder when the wind is up. When the wind pipes up, you do need to reef the mizzen to reduce weather helm, but that isn't a big deal since the mast is right there in the cockpit. Many people don't like having the mast in the cockpit, but I don't mind it. The mizzen on my boat is too big to use an a riding sail when anchored unless I tie in the second reef, so I usually drop the sail once we are anchored.
Single handing it is very easy to sail the boat without the main since all sail handling is done from the cockpit. That is important because I don't have an autopilot