Depends, of course, on how your deck layout might adapt.
When I was reviewing new boats for Cruising World I always tried to insert a comment (basically a complaint) that easing the mainsheet in a gust is mighty hard when you're stuck behind the wheel trying to prevent a roundup and the mainsheet is on the cabintop.
I sailed on a new Jeanneau last year where they had sort-of solved that problem by making the mainsheet double-ended and running one end each side back to the jibsheet winches next to the helms (twin helms, of course . . .). That created its own issues when tacking . . . but . . .
Could you run one end to the currently used cabintop winch and the other back to the helm? That would give you the ability to do a quick ease when necessary and your wife could take it back up in her own time on the cabintop winch. You would have to overhaul the sheet every now and then to rebalance the ends . . .
I wouldn't go with the in-mast furler because you then have the outhaul competing with the mainsheet for that winch . . . along with other issues.
In-boom furlers require precision operating procedures. According to my urologist (who had an in-boom furling system fitted a couple of years ago on his Bristol 40), the mainsail goes up slowly (no jokes, please) because of the unwinding -- an electric winch would help and lowering the sail is very slow because it has to be wound up on the mandrel. Points to consider.
I'm an armchair sailor these days . . . but still have opinions.